Combination of CPAs to reduce cell damage during cryopreservation
Cryoprotective agents (CPAs) are essential to the cryopreservation process because they protect cells from ice formation, which can cause irreversible damage. However, one of the major challenges in cryopreservation is the potential toxicity of CPAs when used at the high concentrations required for effective protection. This toxicity can impair cell viability and functionality—a significant problem when preserving cells for future use.
Innovative solution: Combination of CPAs to reduce toxicity
Advances in cryopreservation technology are leading to increasingly sophisticated solutions. One promising strategy is combining different CPAs to lower the overall concentration of each, thereby reducing their toxic effects while achieving robust cryoprotection.
A recent breakthrough is the use of trehalose in combination with glycerol . Trehalose is a disaccharide known for its ability to protect cells under extreme conditions. In conjunction with glycerol, this combination has been shown to efficiently preserve both the viability and functional integrity of cryopreserved human adipose-derived stem cells.
What does this mean for cryopreservation?
This approach could redefine our perspective on cell preservation. By optimizing CPA formulations, we can significantly improve cryopreservation outcomes, making it more effective and less damaging to cells. Applications are diverse, ranging from biobanking to regenerative medicine, ensuring that preserved cells remain viable and functional when they are needed most.
At Consarctic, we wholeheartedly support and welcome advances in cryopreservation. Innovations like the combination of CPAs are examples of the groundbreaking advances driving our industry forward. While our focus remains on providing state-of-the-art cryosystems and unmatched services, we recognize the critical importance of these developments to the future of cell preservation. We are committed to ensuring that every sample stored with our technologies has the best possible chance of survival, preserving the invaluable potential of biological materials for years to come.
Consarctic is proud to contribute to the success and reliability of cryopreservation worldwide with its advanced, reliable, and precise cryogenics solutions. Together, we strive for a future where every cryopreserved cell, tissue, and organ can be revitalized to its full potential.